Southwell, Amber L.: search on Z-Library

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1

Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases

Southwell, Amber L., Skotte, Niels H., Bennett, C. Frank, Hayden, Michael R.

Journal:

Trends in Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 1.38 MB

english, 2012

2

Inhibiting cellular uptake of mutant huntingtin using a monoclonal antibody: Implications for the treatment of Huntington's disease

Bartl, Stefan, Oueslati, Abid, Southwell, Amber L., Siddu, Alberto, Parth, Michela, David, Linda Suzanne, Maxan, Alexander, Salhat, Nina, Burkert, Markus, Mairhofer, Andreas, Friedrich, Theresa, Panke

Journal:

Neurobiology of Disease

Year:

2020

File:

PDF, 2.74 MB

2020

3

Potent and sustained huntingtin lowering via AAV5 encoding miRNA preserves striatal volume and cognitive function in a humanized mouse model of Huntington disease

Caron, Nicholas S, Southwell, Amber L, Brouwers, Cynthia C, Cengio, Louisa Dal, Xie, Yuanyun, Black, Hailey Findlay, Anderson, Lisa M, Ko, Seunghyun, Zhu, Xiang, van Deventer, Sander J, Evers, Melvin

Journal:

Nucleic Acids Research

Year:

2019

Language:

english

File:

PDF, 11.81 MB

english, 2019

4

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

Ehrnhoefer, Dagmar E., Martin, Dale D. O., Schmidt, Mandi E., Qiu, Xiaofan, Ladha, Safia, Caron, Nicholas S., Skotte, Niels H., Nguyen, Yen T. N., Vaid, Kuljeet, Southwell, Amber L., Engemann, Sabine,

Journal:

Acta Neuropathologica Communications

Year:

2018

Language:

english

File:

PDF, 4.15 MB

english, 2018

5

A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles

Southwell, Amber L., Skotte, Niels H., Villanueva, Erika B., Østergaard, Michael E., Gu, Xiaofeng, Kordasiewicz, Holly B., Kay, Chris, Cheung, Daphne, Xie, Yuanyun, Waltl, Sabine, Dal Cengio, Louisa,

Journal:

Human Molecular Genetics

Year:

2017

Language:

english

File:

PDF, 1.38 MB

english, 2017

6

L5 Pre-clinical evaluation of aav5-mihtt gene therapy of huntington’s disease in rodents

Miniarikova, Jana, Zanella, Ilaria, Blits, Bas, Evers, Melvin, Zimmer, Virginie, Spoerl, Alexia, Southwell, Amber, Hayden, Michael, Deventer, Sander van, Deglon, Nicole, Petry, Harald, Konstantinova,

Journal:

Journal of Neurology Neurosurgery & Psychiatry

Year:

2016

Language:

english

File:

PDF, 77 KB

english, 2016

7

In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides

Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yua

Journal:

Molecular Therapy

Year:

2014

Language:

english

File:

PDF, 5.12 MB

english, 2014

8

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

Southwell, Amber L., Smith-Dijak, Amy, Kay, Chris, Sepers, Marja, Villanueva, Erika B., Parsons, Matthew P., Xie, Yuanyun, Anderson, Lisa, Felczak, Boguslaw, Waltl, Sabine, Ko, Seunghyun, Cheung, Daph

Journal:

Human Molecular Genetics

Year:

2016

Language:

english

File:

PDF, 3.69 MB

english, 2016

9

Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease

Southwell, Amber L., Franciosi, Sonia, Villanueva, Erika B., Xie, Yuanyun, Winter, Laurie A., Veeraraghavan, Janaki, Jonason, Alan, Felczak, Boguslaw, Zhang, Weining, Kovalik, Vlad, Waltl, Sabine, Hal

Journal:

Neurobiology of Disease

Year:

2015

Language:

english

File:

PDF, 2.25 MB

english, 2015

10

Biological Aging and the Cellular Pathogenesis of Huntingtonâs Disease

Machiela, Emily, Southwell, Amber L.

Journal:

Journal of Huntington's Disease

Year:

2020

File:

PDF, 214 KB

2020

11

Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides

Østergaard, Michael E., Thomas, George, Koller, Erich, Southwell, Amber L., Hayden, Michael R., Seth, Punit P.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 471 KB

english, 2015

12

Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression

Southwell, Amber L., Smith, Stephen E.P., Davis, Tessa R., Caron, Nicholas S., Villanueva, Erika B., Xie, Yuanyun, Collins, Jennifer A., Li Ye, Min, Sturrock, Aaron, Leavitt, Blair R., Schrum, Adam G.

Journal:

Scientific Reports

Year:

2015

Language:

english

File:

PDF, 1.14 MB

english, 2015

13

Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease

Southwell, Amber L., Kordasiewicz, Holly B., Langbehn, Douglas, Skotte, Niels H., Parsons, Matthew P., Villanueva, Erika B., Caron, Nicholas S., Østergaard, Michael E., Anderson, Lisa M., Xie, Yuanyun

Journal:

Science Translational Medicine

Year:

2018

Language:

english

File:

PDF, 1.51 MB

english, 2018

14

Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin

Carroll, Jeffrey B, Warby, Simon C, Southwell, Amber L, Doty, Crystal N, Greenlee, Sarah, Skotte, Niels, Hung, Gene, Bennett, C Frank, Freier, Susan M, Hayden, Michael R

Journal:

Molecular Therapy

Year:

2011

Language:

english

File:

PDF, 311 KB

english, 2011

15

Huntingtin Haplotypes Provide Prioritized Target Panels for Allele Specific Silencing in Huntington Disease Patients of European Ancestry

Kay, Chris, Collins, Jennifer A., Skotte, Niels H., Southwell, Amber L., Warby, Simon C., Caron, Nicholas S., Doty, Crystal N., Nguyen, Betty, Griguoli, Annamaria, Ross, Colin J., Squitieri, Ferdinand

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 1.84 MB

english, 2015

16

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo

Ehrnhoefer, Dagmar E, Southwell, Amber L, Sivasubramanian, Meenalochani, Qiu, Xiaofan, Villanueva, Erika B, Xie, Yuanyun, Waltl, Sabine, Anderson, Lisa, Fazeli, Anita, Casal, Lorenzo, Felczak, Bogusla

Journal:

Human Molecular Genetics

Year:

2018

Language:

english

File:

PDF, 891 KB

english, 2018

17

L4 Sustained and strong HTT silencing by AAV5-miHTT as therapy for huntington’s disease

Evers, Melvin, Miniarikova, Jana, Blits, Bas, Spronck, Lisa, Brouwers, Cynthia, Déglon, Nicole, Motlik, Jan, Bankiewicz, Krystof, Southwell, Amber, Haan, Martin de, Richard, Charles, Petry, Harald, Ko

Journal:

Journal of Neurology Neurosurgery & Psychiatry

Year:

2016

Language:

english

File:

PDF, 65 KB

english, 2016

18

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease

Jeffrey B Carroll, Amber L Southwell, Rona K Graham, Jason P Lerch, Dagmar E Ehrnhoefer, Li-Ping Cao, Wei-Ning Zhang, Yu Deng, Nagat Bissada, R Mark Henkelman, Michael R Hayden

Journal:

Molecular Neurodegeneration

Year:

2011

Language:

english

File:

PDF, 440 KB

english, 2011

19

Assessment of Motor Balance and Coordination in Mice using the Balance Beam

Luong, Tinh N., Carlisle, Holly J., Southwell, Amber, Patterson, Paul H.

Journal:

Journal of Visualized Experiments

Year:

2011

Language:

english

File:

PDF, 309 KB

english, 2011

20

696. Pre-Clinical Evaluation of Allele-Specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides

Southwell, Amber L., Skotte, Niels H., Caron, Nicholas, Kordasiewicz, Holly, Oestergaard, Michael, Doty, Crystal N., Villanueva, Erika B., Xie, Yuanyun, Felczak, Boguslaw, Freier, Susan M., Swayze, Er

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 272 KB

english, 2015

21

Antibody Therapy in Neurodegenerative Disease

Southwell, Amber L, Patterson, Paul H

Journal:

Reviews in the Neurosciences

Year:

2010

Language:

english

File:

PDF, 1.62 MB

english, 2010

22

Perceptions of emerging tobacco products and nicotine replacement therapy among pregnant women and women planning a pregnancy

England, Lucinda J., Tong, Van T., Koblitz, Amber, Kish-Doto, Julia, Lynch, Molly M., Southwell, Brian G.

Journal:

Preventive Medicine Reports

Year:

2016

Language:

english

File:

PDF, 255 KB

english, 2016

23

Design, Characterization, and Lead Selection of Therapeutic miRNAs Targeting Huntingtin for Development of Gene Therapy for Huntington’s Disease

Miniarikova, Jana, Zanella, Ilaria, Huseinovic, Angelina, van der Zon, Tom, Hanemaaijer, Evelyn, Martier, Raygene, Koornneef, Annemart, Southwell, Amber L, Hayden, Michael R, van Deventer, Sander J, P

Journal:

Molecular Therapy — Nucleic Acids

Year:

2016

Language:

english

File:

PDF, 11.76 MB

english, 2016

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